Human Nutrition
3. Malnutrition and Deficiency Diseases
Learning outcomes
- I can define malnutrition and distinguish between undernutrition and overnutrition.
- I can identify common nutrient deficiency diseases and their causes.
- I can explain the health consequences of poor nutrition.
- I can describe how nutrient deficiencies can be prevented.
- I can evaluate the relationship between diet and long-term health.
What Is Malnutrition?
Malnutrition occurs when a person's intake or use of energy and nutrients does not adequately meet the body's needs.
Malnutrition does not simply mean "not eating enough."
It can result from:
- too little food
- too much energy intake
- too little of a particular nutrient
- an unbalanced diet
- poor absorption of nutrients
- illness that changes nutrient requirements or losses
Therefore, someone can consume plenty of food and still experience a form of malnutrition.
The Main Forms of Malnutrition
Malnutrition can broadly involve:
Undernutrition
The body receives or absorbs insufficient energy or nutrients.
Micronutrient deficiencies
The body lacks sufficient amounts of particular vitamins or minerals.
Overnutrition
Energy or certain nutrients are consumed in excess relative to the body's needs over time.
These forms can sometimes occur together.
For example, a diet may provide excessive energy while still being deficient in particular vitamins or minerals.
Undernutrition
Undernutrition occurs when the body does not receive or effectively use enough energy, protein, or other nutrients to meet its requirements.
Possible causes include:
- inadequate food intake
- limited access to nutritious food
- illness
- digestive disorders
- poor nutrient absorption
- increased nutritional requirements
- prolonged infection
- highly restrictive diets
Effects of Undernutrition
The effects depend on:
- which nutrients are lacking
- severity
- duration
- age
- health
- individual nutritional requirements
Possible consequences include:
- weight loss
- reduced growth in children
- muscle loss
- fatigue
- reduced physical performance
- impaired immune function
- slower wound healing
- increased vulnerability to illness
Severe or prolonged undernutrition can be life-threatening.
Overnutrition
Overnutrition occurs when the body consistently receives more energy or particular nutrients than it requires.
For energy:
energy intake > energy expenditure over time
can lead to increased energy storage.
Much of this excess energy can eventually be stored as:
body fat
Overnutrition is not simply about eating a large meal occasionally. Long-term dietary patterns are more important.
Health Consequences of Long-Term Overnutrition
Long-term excess energy intake can contribute to excess body fat.
Excess body fat is associated with increased risk of several conditions, including:
- type 2 diabetes
- cardiovascular disease
- high blood pressure
- some cancers
- joint problems
- fatty liver disease
Risk is influenced by many factors, including:
- diet
- physical activity
- genetics
- age
- sleep
- smoking
- environment
- existing health conditions
Diet is important, but it is not the only factor affecting long-term health.
Micronutrient Deficiency
A nutrient deficiency occurs when the body does not have enough of a particular nutrient to maintain normal function.
Micronutrient deficiencies commonly involve:
vitamins
or:
minerals
Examples include deficiencies of:
- iron
- vitamin A
- vitamin C
- vitamin D
- iodine
Why Do Deficiencies Occur?
A deficiency can occur for several reasons.
Insufficient intake
The diet does not contain enough of the nutrient.
Poor absorption
The nutrient is present in food but is not absorbed adequately.
Increased requirements
Growth, pregnancy, illness, or other circumstances can increase nutrient requirements.
Increased loss
Certain illnesses or other conditions can cause nutrients to be lost from the body.
Therefore:
nutrient deficiency does not always mean that someone simply chose the wrong foods.
Iron Deficiency
Iron is required for the production of:
haemoglobin
Haemoglobin is found in red blood cells and carries oxygen.
The relationship is:
iron → haemoglobin → oxygen transport
If insufficient iron is available, the body may be unable to produce enough normal haemoglobin.
Iron-Deficiency Anaemia
One important consequence of iron deficiency is:
iron-deficiency anaemia
A person may experience symptoms such as:
- tiredness
- weakness
- shortness of breath
- reduced exercise tolerance
- difficulty concentrating
These symptoms occur because the blood's ability to transport oxygen can be reduced.
Sources of Iron
Iron-containing foods include:
- meat
- fish
- beans
- lentils
- leafy green vegetables
- fortified cereals
- some seeds and nuts
Vitamin C can improve the absorption of non-haem iron, the form commonly found in plant foods.
For example:
lentils + vitamin C-rich vegetables
can be a useful dietary combination.
Preventing Iron Deficiency
Strategies can include:
- consuming appropriate iron-rich foods
- eating a varied diet
- including vitamin C-rich foods alongside plant sources of iron
- using appropriately fortified foods where available
- addressing medical causes of blood loss or poor absorption
Iron supplements may be recommended in some circumstances, but unnecessary high-dose supplementation can be harmful.
Vitamin C Deficiency
Vitamin C is important for several functions, including:
- collagen formation
- wound healing
- antioxidant activity
- supporting iron absorption
Severe, prolonged vitamin C deficiency can cause:
scurvy
Scurvy
Collagen is an important structural protein.
When vitamin C deficiency interferes with normal collagen production, tissues can become weakened.
Symptoms of scurvy can include:
- bleeding gums
- easy bruising
- poor wound healing
- fatigue
- weakness
Severe cases can cause serious complications.
Preventing Vitamin C Deficiency
Vitamin C is found in many fruits and vegetables.
Sources include:
- oranges and other citrus fruits
- peppers
- strawberries
- broccoli
- tomatoes
- kiwi fruit
A varied diet containing fruits and vegetables generally helps provide adequate vitamin C.
Vitamin D Deficiency
Vitamin D is important for maintaining appropriate calcium and phosphate levels.
It contributes to:
normal bone mineralization
The body can produce vitamin D in the skin when exposed to sufficient ultraviolet B radiation.
Vitamin D can also be obtained from:
- certain fish
- egg yolks
- fortified foods
- supplements when appropriate
Rickets
Severe vitamin D deficiency in growing children can contribute to:
rickets
Rickets involves inadequate mineralization of growing bones.
Possible effects include:
- soft or weak bones
- skeletal deformities
- impaired growth
- bone pain
- muscle weakness
Vitamin D, calcium, and phosphate are closely connected to normal bone development.
Vitamin D Deficiency in Adults
In adults, severe vitamin D deficiency can cause:
osteomalacia
This involves poor mineralization of bone.
It can contribute to:
- bone pain
- muscle weakness
- increased risk of fractures
This is different from osteoporosis, although both can affect bone health.
Preventing Vitamin D Deficiency
Prevention may involve:
- appropriate dietary sources
- fortified foods
- suitable sunlight exposure
- supplementation when medically appropriate
The best approach varies according to:
- age
- skin pigmentation
- location
- season
- lifestyle
- health
- individual risk
Vitamin A Deficiency
Vitamin A is important for:
- vision
- immune function
- growth
- maintenance of epithelial tissues
Severe vitamin A deficiency can affect vision.
One early problem can be:
night blindness
More severe deficiency can damage the eye and potentially lead to blindness.
Sources of Vitamin A
Vitamin A or its precursors can be obtained from foods such as:
- liver
- eggs
- dairy products
- carrots
- sweet potatoes
- pumpkin
- dark green leafy vegetables
Orange and dark green vegetables often contain:
beta-carotene
which the body can convert into vitamin A.
Iodine Deficiency
Iodine is required to make:
thyroid hormones
These hormones contribute to the regulation of:
- metabolism
- growth
- development
Insufficient iodine can interfere with thyroid function.
Goitre
One possible consequence of iodine deficiency is enlargement of the thyroid gland.
This is called:
goitre
The thyroid is located in the neck.
However, goitre can have causes other than iodine deficiency, so the presence of an enlarged thyroid does not by itself identify the cause.
Why Iodine Is Especially Important During Development
Thyroid hormones are particularly important during fetal and early childhood development.
Severe iodine deficiency during pregnancy can interfere with normal brain and nervous-system development.
This demonstrates an important idea:
the same nutrient deficiency can have different consequences at different stages of life.
Preventing Iodine Deficiency
One important public-health strategy is:
iodized salt
Iodized salt contains added iodine.
Other dietary sources may include:
- seafood
- dairy products
- eggs
- some seaweeds
The iodine content of foods varies depending on environmental and agricultural conditions.
Calcium Deficiency and Bone Health
Calcium is important for:
- bones
- teeth
- muscle contraction
- nerve signaling
- blood clotting
Long-term inadequate calcium intake can contribute to poor bone health.
However, bone health depends on more than calcium alone.
Important factors also include:
- vitamin D
- protein
- physical activity
- hormones
- age
- genetics
Protein-Energy Undernutrition
Severe undernutrition can involve inadequate:
energy
and:
protein
Growing children are particularly vulnerable because they require nutrients for both:
maintenance + growth
Severe protein-energy undernutrition can interfere with:
- growth
- muscle development
- immune function
- organ function
- recovery from illness
Marasmus
Marasmus is a severe form of undernutrition associated with major energy deficiency.
It can involve:
- severe wasting
- loss of muscle and body fat
- poor growth
- weakness
The body lacks sufficient energy to maintain normal growth and tissue stores.
Kwashiorkor
Kwashiorkor is a severe form of malnutrition classically associated with severe dietary inadequacy and characterized by features that can include:
- oedema
- changes in skin and hair
- impaired growth
- enlarged fatty liver
Its biology is complex and cannot be explained simply as "protein deficiency alone."
This is an important example of why real nutritional diseases can be more complicated than simplified textbook descriptions.
Deficiency Disease Summary
| Deficiency | Important Function | Possible Consequence |
|---|---|---|
| Iron | Haemoglobin and oxygen transport | Iron-deficiency anaemia |
| Vitamin C | Collagen formation | Scurvy |
| Vitamin D | Calcium regulation and bone mineralization | Rickets in children; osteomalacia in adults |
| Vitamin A | Vision and epithelial health | Night blindness and eye damage |
| Iodine | Thyroid hormone production | Thyroid dysfunction; goitre may occur |
| Severe energy deficiency | Energy for normal body functions | Wasting and impaired growth |
A Deficiency Is Not Always Obvious
Someone can consume enough calories but still lack particular nutrients.
Consider a diet containing large amounts of:
- refined grains
- sugary drinks
- highly processed snack foods
but very little:
- fruit
- vegetables
- protein-rich foods
- varied nutrient sources
The person may consume sufficient or excessive energy while still having inadequate intake of some micronutrients.
This is sometimes described as the:
double burden of malnutrition
The Double Burden of Malnutrition
A population, household, or even an individual can experience different forms of malnutrition simultaneously.
For example:
excess energy intake
may coexist with:
iron deficiency
or another micronutrient deficiency.
This demonstrates why body size alone does not tell us whether someone's nutritional intake is adequate.
Malabsorption
Sometimes the problem is not the amount of nutrient in the diet.
The digestive system may not absorb the nutrient effectively.
This is called:
malabsorption
Conditions affecting the intestine can interfere with absorption of:
- iron
- vitamins
- fats
- carbohydrates
- other nutrients
Therefore:
adequate intake does not always guarantee adequate absorption.
Nutrition and the Digestive System
The pathway from food to body cells involves several stages:
food
↓
digestion
↓
absorption
↓
transport
↓
cellular use
A problem at any stage can affect nutritional status.
For example:
nutrient present in food + poor absorption = possible deficiency
Diet and Long-Term Health
Dietary patterns can influence health over many years.
Long-term patterns associated with better health generally include appropriate amounts and variety of:
- vegetables
- fruits
- whole grains
- legumes
- nuts and seeds
- protein-rich foods
- unsaturated fats
while limiting consistently excessive intake of:
- added sugars
- sodium
- saturated fats
- highly processed foods that displace nutrient-rich foods
Diet and Cardiovascular Health
Cardiovascular disease affects the heart and blood vessels.
Long-term cardiovascular risk can be influenced by factors including:
- blood pressure
- blood cholesterol
- smoking
- diabetes
- physical activity
- body composition
- genetics
- diet
Dietary patterns containing plenty of fibre-rich plant foods and appropriate types of dietary fat can contribute to cardiovascular health.
Diet and Type 2 Diabetes
Type 2 diabetes involves problems with the regulation of blood glucose.
Risk is influenced by multiple factors, including:
- genetics
- age
- body composition
- physical activity
- dietary patterns
Long-term excessive energy intake can contribute to excess body fat, which is an important risk factor for type 2 diabetes.
However:
diet is one risk factor among several
and should not be treated as the sole cause.
Diet and Blood Pressure
Blood pressure is influenced by:
- genetics
- age
- physical activity
- body composition
- diet
- sodium intake
- potassium intake
- alcohol intake
- other health factors
Consistently high sodium intake can contribute to elevated blood pressure, particularly in salt-sensitive individuals.
This is one reason many dietary guidelines recommend limiting excessive sodium intake.
Diet and Bone Health
Bone health depends on long-term nutrition and lifestyle.
Important factors include:
- calcium
- vitamin D
- protein
- physical activity
- hormones
- age
- genetics
Weight-bearing physical activity also helps stimulate bone maintenance.
Therefore:
healthy bones require both nutrition and appropriate physical activity.
Poor Nutrition Can Affect Learning and Performance
Nutrition can influence more than physical growth.
Inadequate nutrition can affect:
- concentration
- energy levels
- physical performance
- recovery
- immune function
For students, adequate nutrition and hydration can therefore support participation in both:
learning
and:
physical activity
Preventing Nutrient Deficiencies
A major strategy is eating a varied, balanced diet.
This can include:
- vegetables
- fruits
- whole grains
- legumes
- protein-rich foods
- appropriate fat sources
- adequate fluids
Different foods supply different nutrients.
Therefore:
dietary variety reduces the risk of missing particular nutrients.
Food Fortification
Food fortification involves adding nutrients to foods.
Examples can include:
- iodine added to salt
- vitamin D added to some foods
- iron added to cereals or flour
- folic acid added to some grain products
Fortification can help increase nutrient intake across large populations.
Supplementation
A dietary supplement provides concentrated amounts of particular nutrients.
Examples include:
- iron
- vitamin D
- vitamin B12
- folic acid
Supplements can be useful when:
- dietary intake is insufficient
- requirements are increased
- absorption is limited
- a deficiency has been diagnosed
- specific public-health guidance recommends them
However:
more is not always better.
Some nutrients can be harmful in excessive amounts.
Prevention Through Public Health
Preventing malnutrition is not only an individual responsibility.
Public-health approaches can include:
- access to nutritious foods
- clean water
- sanitation
- nutrition education
- food fortification
- maternal and infant nutrition programs
- school meal programs
- disease prevention
- healthcare access
Malnutrition therefore involves both:
biology
and:
social and environmental conditions.
Evaluating a Diet for Deficiency Risk
Consider this daily pattern:
Breakfast: sweetened drink
Lunch: white bread and chips
Snack: candy
Dinner: instant noodles
Possible concerns include low intake of:
- fibre
- protein
- iron
- calcium
- some vitamins
- vegetables and fruits
The diet may still provide considerable energy.
This illustrates:
high energy intake does not guarantee adequate nutrition.
Improving the Diet
A more varied pattern could include:
Breakfast: oatmeal + fruit + yoghurt
Lunch: rice + vegetables + beans, tofu, fish, eggs, or chicken
Snack: fruit + nuts
Dinner: whole grains or potatoes + vegetables + protein source
Drinks: mainly water
The goal is to increase:
variety + nutrient density + appropriate balance
rather than simply increasing the amount of food.
Case Study: Fatigue
A student frequently feels tired.
Their diet contains very little iron-rich food.
One possible nutritional explanation could be:
insufficient iron
↓
reduced haemoglobin production
↓
reduced oxygen-carrying capacity
↓
fatigue
However, fatigue has many possible causes.
A symptom alone cannot diagnose a nutrient deficiency.
Case Study: Bone Development
A growing child has very low vitamin D availability.
Possible pathway:
low vitamin D
↓
impaired calcium/phosphate regulation
↓
poor bone mineralization
↓
increased risk of rickets
This demonstrates how a micronutrient can influence an entire organ system.
Case Study: A High-Energy but Low-Quality Diet
A person regularly consumes enough energy but eats very little:
- fruit
- vegetables
- whole grains
- legumes
- varied protein sources
This person is not necessarily undernourished in terms of energy.
However, they could still have inadequate intake of particular:
vitamins, minerals, fibre, or other nutrients.
This is why malnutrition cannot be judged simply by how much someone eats.
Diet Is About Patterns
Eating one highly nutritious meal does not guarantee long-term health.
Eating one less nutritious meal does not create a deficiency disease.
Nutritional health reflects patterns developing over:
days → weeks → months → years
This is especially important when evaluating the relationship between diet and chronic disease.
Risk Is Not Certainty
Suppose a particular dietary pattern is associated with increased risk of a disease.
This does not mean:
diet → guaranteed disease
Instead:
diet + genetics + activity + environment + age + other factors → overall risk
Nutrition often changes the probability of health outcomes rather than determining them completely.
This distinction is essential when interpreting health information.
Evaluating Nutrition Claims
Imagine an advertisement says:
"This drink contains 100% of your daily vitamin C, so it keeps you healthy."
A scientific evaluation should ask:
- What else does the drink contain?
- How much sugar does it contain?
- What is the serving size?
- What other nutrients does it provide?
- What does the person's overall diet look like?
- Does the evidence support the health claim?
One nutrient does not determine the nutritional quality of an entire diet.
Common Misconception: Malnutrition Means Starvation
Starvation is an extreme form of inadequate energy intake.
Malnutrition is a much broader concept.
It can include:
undernutrition
micronutrient deficiency
and:
overnutrition
A person does not need to be starving to be malnourished.
Common Misconception: Someone Who Eats a Lot Cannot Be Malnourished
A person can consume excessive energy while receiving insufficient amounts of particular nutrients.
For example:
high energy + low iron intake
could still contribute to iron deficiency.
Nutritional status depends on:
quality + quantity + absorption + individual needs
Common Misconception: Deficiency Diseases Develop Immediately
Most deficiency diseases develop after inadequate nutrient availability persists.
The body may store some nutrients.
For example, certain vitamins and minerals can be stored to varying degrees.
Therefore, symptoms may appear only after stores become depleted or physiological functions are affected.
Common Misconception: Supplements Prevent Every Deficiency
Supplements can be useful in appropriate circumstances.
However, they cannot automatically compensate for every problem associated with an unbalanced diet.
Foods provide combinations of:
- nutrients
- fibre
- energy
- protein
- fats
- carbohydrates
- other food components
A supplement usually provides only selected substances.
Connecting Malnutrition to Homeostasis
The body attempts to maintain stable internal conditions.
Malnutrition can interfere with this.
For example:
iron deficiency → impaired oxygen transport
water deficiency → impaired fluid balance
iodine deficiency → altered thyroid function
vitamin D deficiency → impaired bone mineralization
energy deficiency → use of body energy stores
Nutrition is therefore closely connected to:
homeostasis
Connecting Malnutrition to Growth
Growing organisms require both:
energy
and:
raw materials
for new tissues.
A child experiencing prolonged undernutrition may have insufficient resources for normal growth.
This can affect:
- height
- muscle development
- bone development
- immune function
- organ development
Good nutrition is therefore particularly important during periods of rapid growth.
Did You Know?
Nutrient deficiencies can sometimes occur even when food appears plentiful.
This is sometimes called hidden hunger.
A person's diet may provide enough calories but insufficient amounts of important micronutrients such as:
- iron
- iodine
- vitamin A
- zinc
The problem may therefore be difficult to recognize simply by looking at how much food is available.
Major Deficiency Relationships
Iron deficiency
↓
less normal haemoglobin production
↓
reduced oxygen transport
↓
iron-deficiency anaemia
Vitamin C deficiency
↓
impaired collagen formation
↓
weakened connective tissues
↓
scurvy
Vitamin D deficiency
↓
impaired calcium and phosphate regulation
↓
poor bone mineralization
↓
rickets in children / osteomalacia in adults
Vitamin A deficiency
↓
impaired visual and epithelial function
↓
night blindness and potentially eye damage
Iodine deficiency
↓
reduced thyroid hormone production
↓
altered thyroid function
↓
goitre may develop
Deficiency Disease Summary
| Nutrient | Major Function | Deficiency Problem | Prevention Approach |
|---|---|---|---|
| Iron | Haemoglobin formation | Iron-deficiency anaemia | Iron-rich foods, fortification, appropriate treatment |
| Vitamin C | Collagen formation | Scurvy | Fruits and vegetables |
| Vitamin D | Bone mineralization | Rickets / osteomalacia | Diet, fortification, appropriate sunlight exposure or supplementation |
| Vitamin A | Vision and tissue health | Night blindness | Varied vitamin A or carotenoid-rich foods |
| Iodine | Thyroid hormones | Thyroid dysfunction/goitre | Iodized salt and appropriate dietary sources |
| Energy/protein | Growth and maintenance | Wasting and impaired growth | Adequate, balanced nutrition |
Key Terms
- Malnutrition: Inadequate, excessive, or imbalanced intake or utilization of energy and nutrients.
- Undernutrition: Insufficient energy or nutrients to meet the body's requirements.
- Overnutrition: Excess intake of energy or nutrients relative to requirements.
- Nutrient deficiency: Inadequate availability of a particular nutrient.
- Deficiency disease: Disease or disorder resulting from inadequate availability of a nutrient.
- Micronutrient: Vitamin or mineral required in relatively small amounts.
- Anaemia: Condition involving insufficient healthy red blood cells or haemoglobin; it has multiple possible causes.
- Iron-deficiency anaemia: Anaemia caused by insufficient available iron.
- Scurvy: Disease caused by severe vitamin C deficiency.
- Rickets: Disorder of bone mineralization in growing children, often associated with severe vitamin D deficiency.
- Osteomalacia: Poor mineralization of adult bone.
- Goitre: Enlargement of the thyroid gland.
- Malabsorption: Inadequate absorption of nutrients from the digestive system.
- Fortification: Addition of nutrients to foods.
- Supplementation: Use of concentrated nutrient preparations to increase intake.
- Nutrient density: Amount of useful nutrients provided relative to energy content.
- Hidden hunger: Micronutrient deficiency despite apparently adequate energy intake.
- Energy balance: Relationship between energy intake and energy expenditure.
- Chronic disease: Health condition that develops or persists over a long period.
- Homeostasis: Maintenance of relatively stable internal conditions.
Key Takeaways
- Malnutrition occurs when energy or nutrient intake or utilization does not adequately match the body's needs.
- Malnutrition does not simply mean starvation.
- Malnutrition includes undernutrition, micronutrient deficiencies, and overnutrition.
- A person can consume enough or excessive energy while still lacking important micronutrients.
- Undernutrition can result from inadequate food intake, disease, poor absorption, or increased requirements.
- Prolonged undernutrition can impair growth, immunity, physical performance, and tissue repair.
- Overnutrition can occur when energy intake consistently exceeds energy expenditure.
- Long-term excessive energy intake can contribute to excess body fat.
- Excess body fat is associated with increased risk of several chronic diseases.
- Iron is required for haemoglobin and oxygen transport.
- Iron deficiency can cause iron-deficiency anaemia.
- Vitamin C is important for collagen formation.
- Severe vitamin C deficiency causes scurvy.
- Vitamin D contributes to calcium regulation and normal bone mineralization.
- Severe vitamin D deficiency can contribute to rickets in children and osteomalacia in adults.
- Vitamin A is important for vision and tissue health.
- Severe vitamin A deficiency can cause night blindness and more serious eye damage.
- Iodine is required for thyroid hormone production.
- Iodine deficiency can interfere with thyroid function and may cause goitre.
- Severe energy and nutrient deficiency can lead to serious forms of undernutrition.
- Nutrient deficiencies may result from inadequate intake, poor absorption, increased requirements, or increased losses.
- A varied and balanced diet helps prevent many nutritional deficiencies.
- Food fortification can help prevent deficiencies across populations.
- Supplements can be useful in specific situations but should not automatically replace a balanced diet.
- Nutritional needs differ with age, growth, activity, pregnancy, illness, and other factors.
- Diet can influence long-term health, but it is one factor among genetics, physical activity, environment, and other influences.
- Associations between diet and disease represent changes in risk, not guarantees that a particular person will develop a disease.
- Nutritional status cannot be determined simply from body size or the amount of food someone eats.
- "Hidden hunger" describes micronutrient deficiencies that can occur even when energy intake appears adequate.
- Long-term health depends on dietary patterns developing over months and years rather than a single meal.
- A useful way to think about nutritional health is: enough energy + enough essential nutrients + appropriate balance + effective absorption = better support for normal growth, function, and long-term health.